Activating signal cointegrator 1 complex subunit 1 (ASCC1)
Homo sapiens — UniProt Q8N9N2
Data last refreshed: (UniProt release unknown)
Key facts
Activating signal cointegrator 1 complex subunit 1 (ASCC1) is a protein from Homo sapiens identified by UniProt accession Q8N9N2, 400 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8N9N2; gene symbol ASCC1.
- Organism: Homo sapiens.
- Length: 400 amino acids.
- Top disease associations (Open Targets): spinal muscular atrophy with congenital bone fractures 2, spinal muscular atrophy and contracture.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Activating signal cointegrator 1 complex subunit 1 |
|---|---|
| UniProt accession | Q8N9N2 |
| Gene | ASCC1 |
| Organism | Homo sapiens |
| Length | 400 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- spinal muscular atrophy with congenital bone fractures 2 · score 0.70
- spinal muscular atrophy · score 0.51
- contracture · score 0.50
- arthrogryposis · score 0.50
- Hypotonia · score 0.50
- Barrett's esophagus · score 0.48
- genetic disorder · score 0.47
- fetal akinesia deformation sequence · score 0.43
- fetal akinesia deformation sequence 1 · score 0.43
- prenatal-onset spinal muscular atrophy with congenital bone fractures · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9N2-F1 | alphafold | PREDICTED | 65.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9N2.
Amino-acid sequence (400 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASCC1?
The strongest Open Targets associations for ASCC1 are spinal muscular atrophy with congenital bone fractures 2, spinal muscular atrophy, contracture, arthrogryposis and Hypotonia.
How long is the ASCC1 protein?
The Homo sapiens ASCC1 protein (UniProt Q8N9N2) is 400 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9N2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9N2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.