Probable E3 ubiquitin-protein ligase TRIML1 (TRIML1)
Homo sapiens — UniProt Q8N9V2
Data last refreshed: (UniProt release unknown)
Key facts
Probable E3 ubiquitin-protein ligase TRIML1 (TRIML1) is a protein from Homo sapiens identified by UniProt accession Q8N9V2, 468 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8N9V2; gene symbol TRIML1.
- Organism: Homo sapiens.
- Length: 468 amino acids.
- Top disease associations (Open Targets): adolescent idiopathic scoliosis, unipolar depression and response to selective serotonin reuptake inhibitor.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase TRIML1 |
|---|---|
| UniProt accession | Q8N9V2 |
| Gene | TRIML1 |
| Organism | Homo sapiens |
| Length | 468 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.27
- unipolar depression · score 0.23
- response to selective serotonin reuptake inhibitor · score 0.23
- pathological myopia · score 0.23
- neurofibrillary tangles measurement · score 0.16
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- xanthine measurement · score 0.08
- metabolite measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9V2-F1 | alphafold | PREDICTED | 85.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9V2.
Amino-acid sequence (468 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIML1?
The strongest Open Targets associations for TRIML1 are adolescent idiopathic scoliosis, unipolar depression, response to selective serotonin reuptake inhibitor, pathological myopia and neurofibrillary tangles measurement.
How long is the TRIML1 protein?
The Homo sapiens TRIML1 protein (UniProt Q8N9V2) is 468 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9V2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9V2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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