Ankyrin repeat domain-containing protein 53 (ANKRD53)
Homo sapiens — UniProt Q8N9V6
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat domain-containing protein 53 (ANKRD53) is a protein from Homo sapiens identified by UniProt accession Q8N9V6, 530 residues long. MolForge cross-references it against 0 known binders and 9 disease associations.
- UniProt accession: Q8N9V6; gene symbol ANKRD53.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum metabolite measurement and gastric adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 53 |
|---|---|
| UniProt accession | Q8N9V6 |
| Gene | ANKRD53 |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- serum metabolite measurement · score 0.03
- gastric adenocarcinoma · score 0.03
- gut microbiome measurement · score 0.02
- cancer · score 0.01
- neoplasm · score 0.01
- colorectal cancer · score 0.01
- chromosome 16 trisomy · score 0.00
- metopic craniosynostosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9V6-F1 | alphafold | PREDICTED | 61.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9V6.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKRD53?
The strongest Open Targets associations for ANKRD53 are neurodegenerative disease, serum metabolite measurement, gastric adenocarcinoma, gut microbiome measurement and cancer.
How long is the ANKRD53 protein?
The Homo sapiens ANKRD53 protein (UniProt Q8N9V6) is 530 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9V6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9V6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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