Protein TOPAZ1 (TOPAZ1)
Homo sapiens — UniProt Q8N9V7
Data last refreshed: (UniProt release unknown)
Key facts
Protein TOPAZ1 (TOPAZ1) is a protein from Homo sapiens identified by UniProt accession Q8N9V7, 1692 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.
- UniProt accession: Q8N9V7; gene symbol TOPAZ1.
- Organism: Homo sapiens.
- Length: 1692 amino acids.
- Top disease associations (Open Targets): visual perception measurement, body fat percentage and gastroesophageal reflux disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein TOPAZ1 |
|---|---|
| UniProt accession | Q8N9V7 |
| Gene | TOPAZ1 |
| Organism | Homo sapiens |
| Length | 1692 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (118)
Diseases linked to this target (Open Targets).
- visual perception measurement · score 0.24
- body fat percentage · score 0.24
- gastroesophageal reflux disease · score 0.19
- lean body mass · score 0.19
- fat body mass · score 0.19
- depressive symptom measurement · score 0.14
- unipolar depression · score 0.10
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9V7-F1 | alphafold | PREDICTED | 50.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9V7.
Amino-acid sequence (1692 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOPAZ1?
The strongest Open Targets associations for TOPAZ1 are visual perception measurement, body fat percentage, gastroesophageal reflux disease, lean body mass and fat body mass.
How long is the TOPAZ1 protein?
The Homo sapiens TOPAZ1 protein (UniProt Q8N9V7) is 1692 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9V7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9V7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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