Dynein axonemal assembly factor 3 (DNAAF3)
Homo sapiens — UniProt Q8N9W5
Data last refreshed: (UniProt release unknown)
Key facts
Dynein axonemal assembly factor 3 (DNAAF3) is a protein from Homo sapiens identified by UniProt accession Q8N9W5, 541 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q8N9W5; gene symbol DNAAF3.
- Organism: Homo sapiens.
- Length: 541 amino acids.
- Top disease associations (Open Targets): primary ciliary dyskinesia, Rare familial disorder with hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 4.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dynein axonemal assembly factor 3 |
|---|---|
| UniProt accession | Q8N9W5 |
| Gene | DNAAF3 |
| Organism | Homo sapiens |
| Length | 541 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- primary ciliary dyskinesia · score 0.75
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.30
- hypertrophic cardiomyopathy 4 · score 0.26
- platelet count · score 0.18
- dilated cardiomyopathy 2A · score 0.16
- hypertrophic cardiomyopathy 7 · score 0.15
- cardiomyopathy, familial restrictive, 1 · score 0.15
- Drugs used in diabetes use measurement · score 0.12
- Heterotaxia · score 0.08
- platelet crit · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9W5-F1 | alphafold | PREDICTED | 79.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9W5.
Amino-acid sequence (541 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAAF3?
The strongest Open Targets associations for DNAAF3 are primary ciliary dyskinesia, Rare familial disorder with hypertrophic cardiomyopathy, hypertrophic cardiomyopathy 4, platelet count and dilated cardiomyopathy 2A.
How long is the DNAAF3 protein?
The Homo sapiens DNAAF3 protein (UniProt Q8N9W5) is 541 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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