Golgi-associated RAB2 interactor protein 2 (GARIN2)
Homo sapiens — UniProt Q8N9W8
Data last refreshed: (UniProt release unknown)
Key facts
Golgi-associated RAB2 interactor protein 2 (GARIN2) is a protein from Homo sapiens identified by UniProt accession Q8N9W8, 422 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q8N9W8; gene symbol GARIN2.
- Organism: Homo sapiens.
- Length: 422 amino acids.
- Top disease associations (Open Targets): unipolar depression, reticulocyte count and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Golgi-associated RAB2 interactor protein 2 |
|---|---|
| UniProt accession | Q8N9W8 |
| Gene | GARIN2 |
| Organism | Homo sapiens |
| Length | 422 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.08
- reticulocyte count · score 0.06
- appendicular lean mass · score 0.05
- Testicular regression syndrome · score 0.04
- high density lipoprotein cholesterol measurement · score 0.04
- hemoglobin H disease · score 0.03
- dominant beta-thalassemia · score 0.03
- glycoprotein storage disease · score 0.03
- hemoglobin C-beta-thalassemia syndrome · score 0.03
- combined immunodeficiency due to OX40 deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9W8-F1 | alphafold | PREDICTED | 55.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9W8.
Amino-acid sequence (422 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GARIN2?
The strongest Open Targets associations for GARIN2 are unipolar depression, reticulocyte count, appendicular lean mass, Testicular regression syndrome and high density lipoprotein cholesterol measurement.
How long is the GARIN2 protein?
The Homo sapiens GARIN2 protein (UniProt Q8N9W8) is 422 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9W8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9W8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.