Leucine-rich repeat-containing protein 75A (LRRC75A)
Homo sapiens — UniProt Q8NAA5
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 75A (LRRC75A) is a protein from Homo sapiens identified by UniProt accession Q8NAA5, 344 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q8NAA5; gene symbol LRRC75A.
- Organism: Homo sapiens.
- Length: 344 amino acids.
- Top disease associations (Open Targets): appendicular lean mass, triple-negative breast cancer and mean corpuscular hemoglobin.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 75A |
|---|---|
| UniProt accession | Q8NAA5 |
| Gene | LRRC75A |
| Organism | Homo sapiens |
| Length | 344 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.06
- triple-negative breast cancer · score 0.05
- mean corpuscular hemoglobin · score 0.03
- neoplasm · score 0.01
- gastrointestinal stromal tumor · score 0.01
- Miyoshi myopathy · score 0.01
- Sepsis · score 0.01
- acute myeloid leukemia · score 0.01
- multiple myeloma · score 0.01
- metastatic neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NAA5-F1 | alphafold | PREDICTED | 74.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NAA5.
Amino-acid sequence (344 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC75A?
The strongest Open Targets associations for LRRC75A are appendicular lean mass, triple-negative breast cancer, mean corpuscular hemoglobin, neoplasm and gastrointestinal stromal tumor.
How long is the LRRC75A protein?
The Homo sapiens LRRC75A protein (UniProt Q8NAA5) is 344 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NAA5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NAA5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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