Structure-specific endonuclease ANKLE1 (ANKLE1)
Homo sapiens — UniProt Q8NAG6
Data last refreshed: (UniProt release unknown)
Key facts
Structure-specific endonuclease ANKLE1 (ANKLE1) is a protein from Homo sapiens identified by UniProt accession Q8NAG6, 615 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q8NAG6; gene symbol ANKLE1.
- Organism: Homo sapiens.
- Length: 615 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mitochondrial DNA measurement and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Structure-specific endonuclease ANKLE1 |
|---|---|
| UniProt accession | Q8NAG6 |
| Gene | ANKLE1 |
| Organism | Homo sapiens |
| Length | 615 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- mitochondrial DNA measurement · score 0.31
- breast carcinoma · score 0.22
- triple-negative breast cancer · score 0.18
- ovarian serous carcinoma · score 0.15
- ovarian carcinoma · score 0.14
- estrogen-receptor negative breast cancer · score 0.14
- body height · score 0.12
- malignant epithelial tumor of ovary · score 0.09
- lung adenocarcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NAG6-F1 | alphafold | PREDICTED | 69.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NAG6.
Amino-acid sequence (615 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKLE1?
The strongest Open Targets associations for ANKLE1 are neurodegenerative disease, mitochondrial DNA measurement, breast carcinoma, triple-negative breast cancer and ovarian serous carcinoma.
How long is the ANKLE1 protein?
The Homo sapiens ANKLE1 protein (UniProt Q8NAG6) is 615 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NAG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NAG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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