Fibronectin type III domain-containing protein 5 (FNDC5)
Homo sapiens — UniProt Q8NAU1
Data last refreshed: (UniProt release unknown)
Key facts
Fibronectin type III domain-containing protein 5 (FNDC5) is a protein from Homo sapiens identified by UniProt accession Q8NAU1, 260 residues long. MolForge cross-references it against 0 known binders and 477 disease associations.
- UniProt accession: Q8NAU1; gene symbol FNDC5.
- Organism: Homo sapiens.
- Length: 260 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and insulin resistance.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fibronectin type III domain-containing protein 5 |
|---|---|
| UniProt accession | Q8NAU1 |
| Gene | FNDC5 |
| Organism | Homo sapiens |
| Length | 260 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (477)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.13
- type 2 diabetes mellitus · score 0.12
- insulin resistance · score 0.11
- polycystic ovary syndrome · score 0.11
- hepatocellular carcinoma · score 0.11
- non-alcoholic fatty liver disease · score 0.11
- cancer · score 0.11
- Obesity · score 0.11
- Prader-Willi syndrome · score 0.10
- chronic kidney disease · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NAU1-F1 | alphafold | PREDICTED | 71.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NAU1.
Amino-acid sequence (260 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FNDC5?
The strongest Open Targets associations for FNDC5 are neurodegenerative disease, type 2 diabetes mellitus, insulin resistance, polycystic ovary syndrome and hepatocellular carcinoma.
How long is the FNDC5 protein?
The Homo sapiens FNDC5 protein (UniProt Q8NAU1) is 260 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NAU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NAU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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