Pre-mRNA-splicing factor 38A (PRPF38A)
Homo sapiens — UniProt Q8NAV1
Data last refreshed: (UniProt release unknown)
Key facts
Pre-mRNA-splicing factor 38A (PRPF38A) is a protein from Homo sapiens identified by UniProt accession Q8NAV1, 312 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q8NAV1; gene symbol PRPF38A.
- Organism: Homo sapiens.
- Length: 312 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Meier-Gorlin syndrome and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pre-mRNA-splicing factor 38A |
|---|---|
| UniProt accession | Q8NAV1 |
| Gene | PRPF38A |
| Organism | Homo sapiens |
| Length | 312 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.27
- Meier-Gorlin syndrome · score 0.12
- body height · score 0.04
- sarcoma · score 0.01
- neoplasm · score 0.00
- hepatocellular carcinoma · score 0.00
- IGA glomerulonephritis · score 0.00
- triple-negative breast cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NAV1-F1 | alphafold | PREDICTED | 71.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NAV1.
Amino-acid sequence (312 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRPF38A?
The strongest Open Targets associations for PRPF38A are neurodegenerative disease, Meier-Gorlin syndrome, body height, sarcoma and neoplasm.
How long is the PRPF38A protein?
The Homo sapiens PRPF38A protein (UniProt Q8NAV1) is 312 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NAV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NAV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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