Protein unc-13 homolog C (UNC13C)

About Protein unc-13 homolog C

Protein unc-13 homolog C (UNC13C) is a protein from Homo sapiens identified by UniProt accession Q8NB66, 2214 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Protein unc-13 homolog C
UniProt accession	Q8NB66
Gene	UNC13C
Organism	Homo sapiens
Length	2214 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

age at menarche · score 0.32
protein measurement · score 0.31
PHF-tau measurement · score 0.29
sex hormone-binding globulin measurement · score 0.26
smoking initiation · score 0.12
Renal cyst · score 0.12
Abnormality of the face · score 0.12
Abnormal finger morphology · score 0.12
Cystic renal dysplasia · score 0.12
Talipes equinovarus · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NB66-F1	alphafold	PREDICTED	61.14	—

Amino-acid sequence (2214 residues)

MVANFFKSLI LPYIHKLCKG MFTKKLGNTN KNKEYRQQKK DQDFPTAGQT KSPKFSYTFK STVKKIAKCS STHNLSTEED EASKEFSLSP TFSYRVAIAN GLQKNAKVTN SDNEDLLQEL SSIESSYSES LNELRSSTEN QAQSTHTMPV RRNRKSSSSL APSEGSSDGE RTLHGLKLGA LRKLRKWKKS QECVSSDSEL STMKKSWGIR SKSLDRTVRN PKTNALEPGF SSSGCISQTH DVMEMIFKEL QGISQIETEL SELRGHVNAL KHSIDEISSS VEVVQSEIEQ LRTGFVQSRR ETRDIHDYIK HLGHMGSKAS LRFLNVTEER FEYVESVVYQ ILIDKMGFSD APNAIKIEFA QRIGHQRDCP NAKPRPILVY FETPQQRDSV LKKSYKLKGT GIGISTDILT HDIRERKEKG IPSSQTYESM AIKLSTPEPK IKKNNWQSPD DSDEDLESDL NRNSYAVLSK SELLTKGSTS KPSSKSHSAR SKNKTANSSR ISNKSDYDKI SSQLPESDIL EKQTTTHYAD ATPLWHSQSD FFTAKLSRSE SDFSKLCQSY SEDFSENQFF TRTNGSSLLS SSDRELWQRK QEGTATLYDS PKDQHLNGGV QGIQGQTETE NTETVDSGMS NGMVCASGDR SHYSDSQLSL HEDLSPWKEW NQGADLGLDS STQEGFDYET NSLFDQQLDV YNKDLEYLGK CHSDLQDDSE SYDLTQDDNS SPCPGLDNEP QGQWVGQYDS YQGANSNELY QNQNQLSMMY RSQSELQSDD SEDAPPKSWH SRLSIDLSDK TFSFPKFGST LQRAKSALEV VWNKSTQSLS GYEDSGSSLM GRFRTLSQST ANESSTTLDS DVYTEPYYYK AEDEEDYTEP VADNETDYVE VMEQVLAKLE NRTSITETDE QMQAYDHLSY ETPYETPQDE GYDGPADDMV SEEGLEPLNE TSAEMEIRED ENQNIPEQPV EITKPKRIRP SFKEAALRAY KKQMAELEEK ILAGDSSSVD EKARIVSGND LDASKFSALQ VCGGAGGGLY GIDSMPDLRR KKTLPIVRDV AMTLAARKSG LSLAMVIRTS LNNEELKMHV FKKTLQALIY PMSSTIPHNF EVWTATTPTY CYECEGLLWG IARQGMKCLE CGVKCHEKCQ DLLNADCLQR AAEKSSKHGA EDKTQTIITA MKERMKIREK NRPEVFEVIQ EMFQISKEDF VQFTKAAKQS VLDGTSKWSA KITITVVSAQ GLQAKDKTGS SDPYVTVQVG KNKRRTKTIF GNLNPVWDEK FYFECHNSTD RIKVRVWDED DDIKSRVKQH FKKESDDFLG QTIVEVRTLS GEMDVWYNLE KRTDKSAVSG AIRLKINVEI KGEEKVAPYH IQYTCLHENL FHYLTEVKSN GGVKIPEVKG DEAWKVFFDD ASQEIVDEFA MRYGIESIYQ AMTHFSCLSS KYMCPGVPAV MSTLLANINA FYAHTTVSTN IQVSASDRFA ATNFGREKFI KLLDQLHNSL RIDLSKYREN FPASNTERLQ DLKSTVDLLT SITFFRMKVL ELQSPPKASM VVKDCVRACL DSTYKYIFDN CHELYSQLTD PSKKQDIPRE DQGPTTKNLD FWPQLITLMV TIIDEDKTAY TPVLNQFPQE LNMGKISAEI MWTLFALDMK YALEEHENQR LCKSTDYMNL HFKVKWFYNE YVRELPAFKD AVPEYSLWFE PFVMQWLDEN EDVSMEFLHG ALGRDKKDGF QQTSEHALFS CSVVDVFAQL NQSFEIIKKL ECPNPEALSH LMRRFAKTIN KVLLQYAAIV SSDFSSHCDK ENVPCILMNN IQQLRVQLEK MFESMGGKEL DSEASTILKE LQVKLSGVLD ELSVTYGESF QVIIEECIKQ MSFELNQMRA NGNTTSNKNS AAMDAEIVLR SLMDFLDKTL SLSAKICEKT VLKRVLKELW KLVLNKIEKQ IVLPPLTDQT GPQMIFIAAK DLGQLSKLKE HMIREDARGL TPRQCAIMEV VLATIKQYFH AGGNGLKKNF LEKSPDLQSL RYALSLYTQT TDALIKKFID TQTSQSRSSK DAVGQISVHV DITATPGTGD HKVTVKVIAI NDLNWQTTAM FRPFVEVCIL GPNLGDKKRK QGTKTKSNTW SPKYNETFQF ILGKENRPGA YELHLSVKDY CFAREDRIIG MTVIQLQNIA EKGSYGAWYP LLKNISMDET GLTILRILSQ RTSDDVAKEF VRLKSETRST EESA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards