Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3)
Homo sapiens — UniProt Q8NBI2
Data last refreshed: (UniProt release unknown)
Key facts
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) is a protein from Homo sapiens identified by UniProt accession Q8NBI2, 242 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.
- UniProt accession: Q8NBI2; gene symbol CYB561A3.
- Organism: Homo sapiens.
- Length: 242 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, skin pigmentation and retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 |
|---|---|
| UniProt accession | Q8NBI2 |
| Gene | CYB561A3 |
| Organism | Homo sapiens |
| Length | 242 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (104)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.18
- skin pigmentation · score 0.07
- retinitis pigmentosa · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- Cataract-microcornea syndrome · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- isolated ectopia lentis · score 0.05
- aniridia · score 0.05
- Posterior polar cataract · score 0.05
- snowflake vitreoretinal degeneration · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBI2-F1 | alphafold | PREDICTED | 92.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBI2.
Amino-acid sequence (242 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYB561A3?
The strongest Open Targets associations for CYB561A3 are Joubert syndrome, skin pigmentation, retinitis pigmentosa, Familial exudative vitreoretinopathy and Cataract-microcornea syndrome.
How long is the CYB561A3 protein?
The Homo sapiens CYB561A3 protein (UniProt Q8NBI2) is 242 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBI2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBI2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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