Equilibrative nucleobase transporter 1 (SLC43A3)
Homo sapiens — UniProt Q8NBI5
Data last refreshed: (UniProt release unknown)
Key facts
Equilibrative nucleobase transporter 1 (SLC43A3) is a protein from Homo sapiens identified by UniProt accession Q8NBI5, 491 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q8NBI5; gene symbol SLC43A3.
- Organism: Homo sapiens.
- Length: 491 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): platelet count, platelet component distribution width and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Equilibrative nucleobase transporter 1 |
|---|---|
| UniProt accession | Q8NBI5 |
| Gene | SLC43A3 |
| Organism | Homo sapiens |
| Length | 491 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- platelet count · score 0.34
- platelet component distribution width · score 0.30
- mean platelet volume · score 0.27
- eosinophil count · score 0.23
- Crohn's disease · score 0.18
- eosinophil percentage of leukocytes · score 0.17
- risk-taking behaviour · score 0.15
- lymphocyte count · score 0.15
- mean corpuscular volume · score 0.12
- pappalysin‐1 measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBI5-F1 | alphafold | PREDICTED | 82.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBI5.
Amino-acid sequence (491 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC43A3?
The strongest Open Targets associations for SLC43A3 are platelet count, platelet component distribution width, mean platelet volume, eosinophil count and Crohn's disease.
How long is the SLC43A3 protein?
The Homo sapiens SLC43A3 protein (UniProt Q8NBI5) is 491 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBI5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBI5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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