About SID1 transmembrane family member 2
SID1 transmembrane family member 2 (SIDT2) is a protein
from Homo sapiens identified by UniProt accession
Q8NBJ9, 832 residues long.
MolForge cross-references it against 0 known binders and
220 disease associations.
Target properties
| Protein name | SID1 transmembrane family member 2 |
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| UniProt accession | Q8NBJ9 |
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| Gene | SIDT2 |
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| Organism | Homo sapiens |
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| Length | 832 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (220)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.45
- triglyceride:HDL cholesterol ratio · score 0.37
- apolipoprotein A 1 measurement · score 0.24
- body mass index · score 0.20
- monocyte count · score 0.19
- blood protein measurement · score 0.17
- systolic blood pressure · score 0.15
- hypertension · score 0.12
- Calcium channel blocker use measurement · score 0.11
- diastolic blood pressure · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8NBJ9-F1 | alphafold | PREDICTED | 80.25 | — |
Amino-acid sequence (832 residues)
MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI YTFNHTVTRN RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR GMFQRKYLYQ KVERTLCQPP TKNESEIQFF YVDVSTLSPV NTTYQLRVSR MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS NSFYVVVVVK TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG SSPYEGYNYG SFENVSGSTD GLVDSAGTGD LSYGYQGRSF EPVGTRPRVD SMSSVEEDDY DTLTDIDSDK NVIRTKQYLY VADLARKDKR VLRKKYQIYF WNIATIAVFY ALPVVQLVIT YQTVVNVTGN QDICYYNFLC AHPLGNLSAF NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLCALE CGIPKHFGLF YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSII HIIATLLLST QLYYMGRWKL DSGIFRRILH VLYTDCIRQC SGPLYVDRMV LLVMGNVINW SLAAYGLIMR PNDFASYLLA IGICNLLLYF AFYIIMKLRS GERIKLIPLL CIVCTSVVWG FALFFFFQGL STWQKTPAES REHNRDCILL DFFDDHDIWH FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF
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