Protein O-glucosyltransferase 1 (POGLUT1)

About Protein O-glucosyltransferase 1

Protein O-glucosyltransferase 1 (POGLUT1) is a protein from Homo sapiens identified by UniProt accession Q8NBL1, 392 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Protein O-glucosyltransferase 1
UniProt accession	Q8NBL1
Gene	POGLUT1
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

Dowling-Degos disease · score 0.64
Autosomal recessive limb-girdle muscular dystrophy due to ISPD deficiency · score 0.63
neurodegenerative disease · score 0.52
autosomal recessive limb-girdle muscular dystrophy · score 0.37
blood protein measurement · score 0.31
ovarian cancer · score 0.23
endometrial cancer · score 0.23
head and neck squamous cell carcinoma · score 0.23
breast adenocarcinoma · score 0.23
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NBL1-F1	alphafold	PREDICTED	93.07	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBL1.

Amino-acid sequence (392 residues)

MEWWASSPLR LWLLLFLLPS AQGRQKESGS KWKVFIDQIN RSLENYEPCS SQNCSCYHGV IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ ITKNRLYREN DCMFPSRCSG VEHFILEVIG RLPDMEMVIN VRDYPQVPKW MEPAIPVFSF SKTSEYHDIM YPAWTFWEGG PAVWPIYPTG LGRWDLFRED LVRSAAQWPW KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ AWKSMKDTLG KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFIRNHL QMDDITCYWE NLLSEYSKFL SYNVTRRKGY DQIIPKMLKT EL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards