Estradiol 17-beta-dehydrogenase 11 (HSD17B11)
Homo sapiens — UniProt Q8NBQ5
Data last refreshed: (UniProt release unknown)
Key facts
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) is a protein from Homo sapiens identified by UniProt accession Q8NBQ5, 300 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: Q8NBQ5; gene symbol HSD17B11.
- Organism: Homo sapiens.
- Length: 300 amino acids.
- Top disease associations (Open Targets): lean body mass, vitamin D measurement and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Estradiol 17-beta-dehydrogenase 11 |
|---|---|
| UniProt accession | Q8NBQ5 |
| Gene | HSD17B11 |
| Organism | Homo sapiens |
| Length | 300 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.29
- vitamin D measurement · score 0.24
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.11
- platelet count · score 0.09
- sex hormone-binding globulin measurement · score 0.09
- intelligence · score 0.08
- testosterone measurement · score 0.08
- protein measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBQ5-F1 | alphafold | PREDICTED | 93.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBQ5.
Amino-acid sequence (300 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSD17B11?
The strongest Open Targets associations for HSD17B11 are lean body mass, vitamin D measurement, ovarian cancer, squamous cell lung carcinoma and head and neck squamous cell carcinoma.
How long is the HSD17B11 protein?
The Homo sapiens HSD17B11 protein (UniProt Q8NBQ5) is 300 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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