Ubiquitin carboxyl-terminal hydrolase MINDY-2 (MINDY2)
Homo sapiens — UniProt Q8NBR6
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase MINDY-2 (MINDY2) is a protein from Homo sapiens identified by UniProt accession Q8NBR6, 621 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q8NBR6; gene symbol MINDY2.
- Organism: Homo sapiens.
- Length: 621 amino acids.
- Top disease associations (Open Targets): cortical thickness, body mass index and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase MINDY-2 |
|---|---|
| UniProt accession | Q8NBR6 |
| Gene | MINDY2 |
| Organism | Homo sapiens |
| Length | 621 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.22
- body mass index · score 0.16
- Alzheimer disease · score 0.14
- family history of Alzheimer’s disease · score 0.14
- blood metabolite measurement · score 0.09
- lipoprotein measurement · score 0.09
- schizophrenia · score 0.09
- diastolic blood pressure · score 0.09
- late-onset Alzheimers disease · score 0.09
- drug use measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBR6-F1 | alphafold | PREDICTED | 63.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBR6.
Amino-acid sequence (621 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MINDY2?
The strongest Open Targets associations for MINDY2 are cortical thickness, body mass index, Alzheimer disease, family history of Alzheimer’s disease and blood metabolite measurement.
How long is the MINDY2 protein?
The Homo sapiens MINDY2 protein (UniProt Q8NBR6) is 621 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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