Thioredoxin domain-containing protein 5 (TXNDC5)
Homo sapiens — UniProt Q8NBS9
Data last refreshed: (UniProt release unknown)
Key facts
Thioredoxin domain-containing protein 5 (TXNDC5) is a protein from Homo sapiens identified by UniProt accession Q8NBS9, 432 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.
- UniProt accession: Q8NBS9; gene symbol TXNDC5.
- Organism: Homo sapiens.
- Length: 432 amino acids.
- Top disease associations (Open Targets): body height, sitting height measurement and brain stem volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thioredoxin domain-containing protein 5 |
|---|---|
| UniProt accession | Q8NBS9 |
| Gene | TXNDC5 |
| Organism | Homo sapiens |
| Length | 432 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (136)
Diseases linked to this target (Open Targets).
- body height · score 0.41
- sitting height measurement · score 0.33
- brain stem volume measurement · score 0.31
- brain volume measurement · score 0.31
- mean corpuscular hemoglobin · score 0.29
- mean corpuscular hemoglobin concentration · score 0.27
- FEV/FVC ratio · score 0.26
- protein measurement · score 0.21
- mean corpuscular volume · score 0.18
- drug use measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBS9-F1 | alphafold | PREDICTED | 80.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBS9.
Amino-acid sequence (432 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TXNDC5?
The strongest Open Targets associations for TXNDC5 are body height, sitting height measurement, brain stem volume measurement, brain volume measurement and mean corpuscular hemoglobin.
How long is the TXNDC5 protein?
The Homo sapiens TXNDC5 protein (UniProt Q8NBS9) is 432 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBS9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBS9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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