POC1 centriolar protein homolog A (POC1A)
Homo sapiens — UniProt Q8NBT0
Data last refreshed: (UniProt release unknown)
Key facts
POC1 centriolar protein homolog A (POC1A) is a protein from Homo sapiens identified by UniProt accession Q8NBT0, 407 residues long. MolForge cross-references it against 0 known binders and 198 disease associations.
- UniProt accession: Q8NBT0; gene symbol POC1A.
- Organism: Homo sapiens.
- Length: 407 amino acids.
- Top disease associations (Open Targets): short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome, isolated growth hormone deficiency type IA and insulin resistance.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | POC1 centriolar protein homolog A |
|---|---|
| UniProt accession | Q8NBT0 |
| Gene | POC1A |
| Organism | Homo sapiens |
| Length | 407 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (198)
Diseases linked to this target (Open Targets).
- short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome · score 0.77
- isolated growth hormone deficiency type IA · score 0.60
- insulin resistance · score 0.37
- Insulin resistance · score 0.37
- Primary microcephaly · score 0.37
- autosomal recessive primary microcephaly · score 0.37
- argininosuccinic aciduria · score 0.34
- Non-acquired isolated growth hormone deficiency · score 0.26
- platelet count · score 0.22
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NBT0-F1 | alphafold | PREDICTED | 84.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NBT0.
Amino-acid sequence (407 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POC1A?
The strongest Open Targets associations for POC1A are short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome, isolated growth hormone deficiency type IA, insulin resistance, Insulin resistance and Primary microcephaly.
How long is the POC1A protein?
The Homo sapiens POC1A protein (UniProt Q8NBT0) is 407 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NBT0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NBT0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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