E3 ubiquitin-protein ligase RNF149 (RNF149)
Homo sapiens — UniProt Q8NC42
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF149 (RNF149) is a protein from Homo sapiens identified by UniProt accession Q8NC42, 400 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q8NC42; gene symbol RNF149.
- Organism: Homo sapiens.
- Length: 400 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hepatocellular carcinoma and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF149 |
|---|---|
| UniProt accession | Q8NC42 |
| Gene | RNF149 |
| Organism | Homo sapiens |
| Length | 400 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- hepatocellular carcinoma · score 0.07
- acute myeloid leukemia · score 0.07
- neoplasm · score 0.06
- neutrophil count · score 0.03
- smoking status measurement · score 0.03
- carotid artery intima media thickness · score 0.03
- esophageal squamous cell carcinoma · score 0.03
- myeloid white cell count · score 0.02
- myocardial infarction · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NC42-F1 | alphafold | PREDICTED | 74.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NC42.
Amino-acid sequence (400 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF149?
The strongest Open Targets associations for RNF149 are neurodegenerative disease, hepatocellular carcinoma, acute myeloid leukemia, neoplasm and neutrophil count.
How long is the RNF149 protein?
The Homo sapiens RNF149 protein (UniProt Q8NC42) is 400 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NC42 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NC42 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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