SERPINE1 mRNA-binding protein 1 (SERBP1)
Homo sapiens — UniProt Q8NC51
Data last refreshed: (UniProt release unknown)
Key facts
SERPINE1 mRNA-binding protein 1 (SERBP1) is a protein from Homo sapiens identified by UniProt accession Q8NC51, 408 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q8NC51; gene symbol SERBP1.
- Organism: Homo sapiens.
- Length: 408 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, FEV/FVC ratio and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SERPINE1 mRNA-binding protein 1 |
|---|---|
| UniProt accession | Q8NC51 |
| Gene | SERBP1 |
| Organism | Homo sapiens |
| Length | 408 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- FEV/FVC ratio · score 0.21
- creatinine measurement · score 0.16
- cancer · score 0.09
- blood protein measurement · score 0.08
- systemic lupus erythematosus · score 0.08
- glioblastoma multiforme · score 0.08
- parental genotype effect measurement · score 0.07
- birth weight · score 0.07
- optic disc size measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NC51-F1 | alphafold | PREDICTED | 54.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NC51.
Amino-acid sequence (408 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SERBP1?
The strongest Open Targets associations for SERBP1 are neurodegenerative disease, FEV/FVC ratio, creatinine measurement, cancer and blood protein measurement.
How long is the SERBP1 protein?
The Homo sapiens SERBP1 protein (UniProt Q8NC51) is 408 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NC51 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NC51 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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