Carbohydrate sulfotransferase 4 (CHST4)
Homo sapiens — UniProt Q8NCG5
Data last refreshed: (UniProt release unknown)
Key facts
Carbohydrate sulfotransferase 4 (CHST4) is a protein from Homo sapiens identified by UniProt accession Q8NCG5, 386 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q8NCG5; gene symbol CHST4.
- Organism: Homo sapiens.
- Length: 386 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, hepatocellular carcinoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carbohydrate sulfotransferase 4 |
|---|---|
| UniProt accession | Q8NCG5 |
| Gene | CHST4 |
| Organism | Homo sapiens |
| Length | 386 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.13
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.09
- cholangiocarcinoma · score 0.08
- fat body mass · score 0.05
- malignant pleural mesothelioma · score 0.05
- Hepatic veno-occlusive disease - immunodeficiency · score 0.05
- lean body mass · score 0.05
- hyper-IgM syndrome type 3 · score 0.04
- hyper-IgM syndrome type 5 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCG5-F1 | alphafold | PREDICTED | 90.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCG5.
Amino-acid sequence (386 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHST4?
The strongest Open Targets associations for CHST4 are glioblastoma multiforme, hepatocellular carcinoma, neoplasm, cholangiocarcinoma and fat body mass.
How long is the CHST4 protein?
The Homo sapiens CHST4 protein (UniProt Q8NCG5) is 386 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCG5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCG5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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