Diacylglycerol lipase-beta (DAGLB)
Homo sapiens — UniProt Q8NCG7
Data last refreshed: (UniProt release unknown)
Key facts
Diacylglycerol lipase-beta (DAGLB) is a protein from Homo sapiens identified by UniProt accession Q8NCG7, 672 residues long. MolForge cross-references it against 1 known binders and 83 disease associations.
- UniProt accession: Q8NCG7; gene symbol DAGLB.
- Organism: Homo sapiens.
- Length: 672 amino acids.
- Top disease associations (Open Targets): osteogenesis imperfecta, type 21, monocyte count and mean platelet volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Diacylglycerol lipase-beta |
|---|---|
| UniProt accession | Q8NCG7 |
| Gene | DAGLB |
| Organism | Homo sapiens |
| Length | 672 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- osteogenesis imperfecta, type 21 · score 0.50
- monocyte count · score 0.45
- mean platelet volume · score 0.43
- lymphocyte count · score 0.43
- Red cell distribution width · score 0.41
- neutrophil count · score 0.41
- monocyte percentage of leukocytes · score 0.40
- neutrophil percentage of leukocytes · score 0.39
- high density lipoprotein cholesterol measurement · score 0.38
- lymphocyte percentage of leukocytes · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCG7-F1 | alphafold | PREDICTED | 72.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCG7.
Amino-acid sequence (672 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DAGLB?
The strongest Open Targets associations for DAGLB are osteogenesis imperfecta, type 21, monocyte count, mean platelet volume, lymphocyte count and Red cell distribution width.
How long is the DAGLB protein?
The Homo sapiens DAGLB protein (UniProt Q8NCG7) is 672 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCG7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCG7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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