Carbohydrate sulfotransferase 14 (CHST14)
Homo sapiens — UniProt Q8NCH0
Data last refreshed: (UniProt release unknown)
Key facts
Carbohydrate sulfotransferase 14 (CHST14) is a protein from Homo sapiens identified by UniProt accession Q8NCH0, 376 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q8NCH0; gene symbol CHST14.
- Organism: Homo sapiens.
- Length: 376 amino acids.
- Top disease associations (Open Targets): Ehlers-Danlos syndrome, musculocontractural type, Abnormality of the cardiovascular system and Ehlers-Danlos syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carbohydrate sulfotransferase 14 |
|---|---|
| UniProt accession | Q8NCH0 |
| Gene | CHST14 |
| Organism | Homo sapiens |
| Length | 376 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- Ehlers-Danlos syndrome, musculocontractural type · score 0.75
- Abnormality of the cardiovascular system · score 0.45
- Ehlers-Danlos syndrome · score 0.42
- pyknoachondrogenesis · score 0.04
- familial primary pulmonary hypoplasia · score 0.04
- congenital diaphragmatic hernia · score 0.04
- breast carcinoma · score 0.04
- triglyceride measurement · score 0.02
- myopathy · score 0.01
- astrocytoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCH0-F1 | alphafold | PREDICTED | 82.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCH0.
Amino-acid sequence (376 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHST14?
The strongest Open Targets associations for CHST14 are Ehlers-Danlos syndrome, musculocontractural type, Abnormality of the cardiovascular system, Ehlers-Danlos syndrome, pyknoachondrogenesis and familial primary pulmonary hypoplasia.
How long is the CHST14 protein?
The Homo sapiens CHST14 protein (UniProt Q8NCH0) is 376 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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