SPRY domain-containing protein 3 (SPRYD3)
Homo sapiens — UniProt Q8NCJ5
Data last refreshed: (UniProt release unknown)
Key facts
SPRY domain-containing protein 3 (SPRYD3) is a protein from Homo sapiens identified by UniProt accession Q8NCJ5, 442 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q8NCJ5; gene symbol SPRYD3.
- Organism: Homo sapiens.
- Length: 442 amino acids.
- Top disease associations (Open Targets): body height, BMI-adjusted hip circumference and type 1 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPRY domain-containing protein 3 |
|---|---|
| UniProt accession | Q8NCJ5 |
| Gene | SPRYD3 |
| Organism | Homo sapiens |
| Length | 442 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- body height · score 0.28
- BMI-adjusted hip circumference · score 0.22
- type 1 diabetes mellitus · score 0.22
- hypertension, pregnancy-induced · score 0.19
- brain measurement · score 0.16
- toxemia of pregnancy · score 0.15
- hypertension · score 0.12
- osteoarthritis, knee · score 0.06
- medical procedure · score 0.06
- retinitis pigmentosa · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCJ5-F1 | alphafold | PREDICTED | 81.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCJ5.
Amino-acid sequence (442 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPRYD3?
The strongest Open Targets associations for SPRYD3 are body height, BMI-adjusted hip circumference, type 1 diabetes mellitus, hypertension, pregnancy-induced and brain measurement.
How long is the SPRYD3 protein?
The Homo sapiens SPRYD3 protein (UniProt Q8NCJ5) is 442 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.