Voltage-gated delayed rectifier potassium channel KCNH5 (KCNH5)
Homo sapiens — UniProt Q8NCM2
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated delayed rectifier potassium channel KCNH5 (KCNH5) is a protein from Homo sapiens identified by UniProt accession Q8NCM2, 988 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q8NCM2; gene symbol KCNH5.
- Organism: Homo sapiens.
- Length: 988 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and developmental and epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated delayed rectifier potassium channel KCNH5 |
|---|---|
| UniProt accession | Q8NCM2 |
| Gene | KCNH5 |
| Organism | Homo sapiens |
| Length | 988 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- developmental and epileptic encephalopathy · score 0.54
- developmental and epileptic encephalopathy, 12 · score 0.50
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- genetic disorder · score 0.41
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCM2-F1 | alphafold | PREDICTED | 72.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCM2.
Amino-acid sequence (988 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNH5?
The strongest Open Targets associations for KCNH5 are multiple sclerosis, Myasthenia gravis, developmental and epileptic encephalopathy, developmental and epileptic encephalopathy, 12 and Muscle weakness.
How long is the KCNH5 protein?
The Homo sapiens KCNH5 protein (UniProt Q8NCM2) is 988 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCM2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCM2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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