E3 ubiquitin-protein ligase RNF169 (RNF169)
Homo sapiens — UniProt Q8NCN4
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF169 (RNF169) is a protein from Homo sapiens identified by UniProt accession Q8NCN4, 708 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8NCN4; gene symbol RNF169.
- Organism: Homo sapiens.
- Length: 708 amino acids.
- Top disease associations (Open Targets): lean body mass, body height and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF169 |
|---|---|
| UniProt accession | Q8NCN4 |
| Gene | RNF169 |
| Organism | Homo sapiens |
| Length | 708 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.35
- body height · score 0.32
- appendicular lean mass · score 0.29
- base metabolic rate measurement · score 0.24
- fat body mass · score 0.21
- whole body water mass · score 0.17
- sitting height measurement · score 0.12
- pancreatic adenocarcinoma · score 0.07
- grip strength measurement · score 0.07
- colorectal cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCN4-F1 | alphafold | PREDICTED | 54.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCN4.
Amino-acid sequence (708 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF169?
The strongest Open Targets associations for RNF169 are lean body mass, body height, appendicular lean mass, base metabolic rate measurement and fat body mass.
How long is the RNF169 protein?
The Homo sapiens RNF169 protein (UniProt Q8NCN4) is 708 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCN4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCN4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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