Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR)
Homo sapiens — UniProt Q8NCN5
Data last refreshed: (UniProt release unknown)
Key facts
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPR) is a protein from Homo sapiens identified by UniProt accession Q8NCN5, 879 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q8NCN5; gene symbol PDPR.
- Organism: Homo sapiens.
- Length: 879 amino acids.
- Top disease associations (Open Targets): Parkinson disease, lysosomal storage disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial |
|---|---|
| UniProt accession | Q8NCN5 |
| Gene | PDPR |
| Organism | Homo sapiens |
| Length | 879 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.22
- lysosomal storage disease · score 0.22
- Alzheimer disease · score 0.22
- multiple sclerosis · score 0.22
- neurodegenerative disease · score 0.22
- haptoglobin measurement · score 0.21
- lymphocyte count · score 0.14
- protein measurement · score 0.08
- amino acid measurement · score 0.08
- blood metabolite measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCN5-F1 | alphafold | PREDICTED | 90.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCN5.
Amino-acid sequence (879 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PDPR?
The strongest Open Targets associations for PDPR are Parkinson disease, lysosomal storage disease, Alzheimer disease, multiple sclerosis and neurodegenerative disease.
How long is the PDPR protein?
The Homo sapiens PDPR protein (UniProt Q8NCN5) is 879 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCN5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCN5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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