UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2)
Homo sapiens — UniProt Q8NCR0
Data last refreshed: (UniProt release unknown)
Key facts
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2) is a protein from Homo sapiens identified by UniProt accession Q8NCR0, 500 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8NCR0; gene symbol B3GALNT2.
- Organism: Homo sapiens.
- Length: 500 amino acids.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11, genetic disorder and muscular dystrophy-dystroglycanopathy, type A.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 |
|---|---|
| UniProt accession | Q8NCR0 |
| Gene | B3GALNT2 |
| Organism | Homo sapiens |
| Length | 500 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11 · score 0.81
- genetic disorder · score 0.38
- muscular dystrophy-dystroglycanopathy, type A · score 0.37
- muscle-eye-brain disease · score 0.37
- autosomal recessive non-syndromic intellectual disability · score 0.37
- body mass index · score 0.30
- blood protein measurement · score 0.27
- body weight · score 0.23
- hypoparathyroidism-retardation-dysmorphism syndrome · score 0.18
- mathematical ability · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCR0-F1 | alphafold | PREDICTED | 86.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCR0.
Amino-acid sequence (500 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with B3GALNT2?
The strongest Open Targets associations for B3GALNT2 are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11, genetic disorder, muscular dystrophy-dystroglycanopathy, type A, muscle-eye-brain disease and autosomal recessive non-syndromic intellectual disability.
How long is the B3GALNT2 protein?
The Homo sapiens B3GALNT2 protein (UniProt Q8NCR0) is 500 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCR0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCR0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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