Protein MFI (MFI)

About Protein MFI

Protein MFI (MFI) is a protein from Homo sapiens identified by UniProt accession Q8NCR3, 313 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Protein MFI
UniProt accession	Q8NCR3
Gene	MFI
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

ataxia telangiectasia · score 0.66
Ataxia-telangiectasia · score 0.66
hereditary breast carcinoma · score 0.59
hereditary neoplastic syndrome · score 0.58
Inherited cancer-predisposing syndrome · score 0.58
breast carcinoma · score 0.57
Hereditary breast and ovarian cancer syndrome · score 0.55
breast cancer · score 0.54
gastric cancer · score 0.54
susceptibility to breast cancer · score 0.52

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NCR3-F1	alphafold	PREDICTED	74.46	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCR3.

Amino-acid sequence (313 residues)

MPWKEESEFT KQDKAARVIQ QAWKSFLNVA IFQHFKSLID LRRQGEPRQI VKYINPKEAE LLDAAAGIHV RFRLGGVKFP PDIYYKIFTH RPIEDLCANS PRNYAKLPAK HTSHNKNDHL QEEDHSGWYH RIENNGWRPV SDTFWLSTDG MVVEDKKESE FHFSKLKRRQ DLEKKRKLRK IEWMRQMYYS GSLEAKSTHH ETLGLIHTAT KGLIRAFEDG GIDSVMEWEV DEVLNWTNTL NFDEYIASWK EIATSNSSAN FKGFRFNQAQ KNIYNYGGDI SKMQMGIPDD TYYENVYQEP NVTRLTPDST YGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards