Protein MFI (MFI)
Homo sapiens — UniProt Q8NCR3
Data last refreshed: (UniProt release unknown)
Key facts
Protein MFI (MFI) is a protein from Homo sapiens identified by UniProt accession Q8NCR3, 313 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.
- UniProt accession: Q8NCR3; gene symbol MFI.
- Organism: Homo sapiens.
- Length: 313 amino acids.
- Top disease associations (Open Targets): ataxia telangiectasia, Ataxia-telangiectasia and hereditary breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein MFI |
|---|---|
| UniProt accession | Q8NCR3 |
| Gene | MFI |
| Organism | Homo sapiens |
| Length | 313 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (95)
Diseases linked to this target (Open Targets).
- ataxia telangiectasia · score 0.66
- Ataxia-telangiectasia · score 0.66
- hereditary breast carcinoma · score 0.59
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.58
- breast carcinoma · score 0.57
- Hereditary breast and ovarian cancer syndrome · score 0.55
- breast cancer · score 0.54
- gastric cancer · score 0.54
- susceptibility to breast cancer · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCR3-F1 | alphafold | PREDICTED | 74.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCR3.
Amino-acid sequence (313 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MFI?
The strongest Open Targets associations for MFI are ataxia telangiectasia, Ataxia-telangiectasia, hereditary breast carcinoma, hereditary neoplastic syndrome and Inherited cancer-predisposing syndrome.
How long is the MFI protein?
The Homo sapiens MFI protein (UniProt Q8NCR3) is 313 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCR3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCR3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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