Mitoregulin (MTLN)
Homo sapiens — UniProt Q8NCU8
Data last refreshed: (UniProt release unknown)
Key facts
Mitoregulin (MTLN) is a protein from Homo sapiens identified by UniProt accession Q8NCU8, 56 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8NCU8; gene symbol MTLN.
- Organism: Homo sapiens.
- Length: 56 amino acids.
- Top disease associations (Open Targets): nephronophthisis 1, Senior-Loken syndrome and cone dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitoregulin |
|---|---|
| UniProt accession | Q8NCU8 |
| Gene | MTLN |
| Organism | Homo sapiens |
| Length | 56 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- nephronophthisis 1 · score 0.33
- Senior-Loken syndrome · score 0.33
- cone dystrophy · score 0.26
- malignant pleural mesothelioma · score 0.03
- Insulin resistance · score 0.01
- neoplasm · score 0.01
- hepatocellular carcinoma · score 0.01
- multiple myeloma · score 0.01
- Nephronophthisis · score 0.01
- non-small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCU8-F1 | alphafold | PREDICTED | 89.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCU8.
Amino-acid sequence (56 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTLN?
The strongest Open Targets associations for MTLN are nephronophthisis 1, Senior-Loken syndrome, cone dystrophy, malignant pleural mesothelioma and Insulin resistance.
How long is the MTLN protein?
The Homo sapiens MTLN protein (UniProt Q8NCU8) is 56 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCU8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCU8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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