Adenosine deaminase domain-containing protein 2 (ADAD2)
Homo sapiens — UniProt Q8NCV1
Data last refreshed: (UniProt release unknown)
Key facts
Adenosine deaminase domain-containing protein 2 (ADAD2) is a protein from Homo sapiens identified by UniProt accession Q8NCV1, 583 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.
- UniProt accession: Q8NCV1; gene symbol ADAD2.
- Organism: Homo sapiens.
- Length: 583 amino acids.
- Top disease associations (Open Targets): azoospermia, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Adenosine deaminase domain-containing protein 2 |
|---|---|
| UniProt accession | Q8NCV1 |
| Gene | ADAD2 |
| Organism | Homo sapiens |
| Length | 583 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (111)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.37
- partial chromosome Y deletion · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- spermatogenic failure 61 · score 0.10
- spermatogenic failure 59 · score 0.10
- spermatogenic failure 74 · score 0.10
- spermatogenic failure 73 · score 0.10
- spermatogenic failure 48 · score 0.10
- spermatogenic failures 50 · score 0.10
- habitual abortion · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCV1-F1 | alphafold | PREDICTED | 75.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCV1.
Amino-acid sequence (583 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAD2?
The strongest Open Targets associations for ADAD2 are azoospermia, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation, spermatogenic failure 61 and spermatogenic failure 59.
How long is the ADAD2 protein?
The Homo sapiens ADAD2 protein (UniProt Q8NCV1) is 583 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCV1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCV1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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