Kremen protein 2 (KREMEN2)
Homo sapiens — UniProt Q8NCW0
Data last refreshed: (UniProt release unknown)
Key facts
Kremen protein 2 (KREMEN2) is a protein from Homo sapiens identified by UniProt accession Q8NCW0, 462 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8NCW0; gene symbol KREMEN2.
- Organism: Homo sapiens.
- Length: 462 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, balding measurement and ependymoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kremen protein 2 |
|---|---|
| UniProt accession | Q8NCW0 |
| Gene | KREMEN2 |
| Organism | Homo sapiens |
| Length | 462 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.19
- balding measurement · score 0.18
- ependymoma · score 0.11
- non-small cell lung carcinoma · score 0.09
- calf circumference measurement · score 0.08
- neoplasm · score 0.06
- cancer · score 0.05
- Osteoporosis · score 0.02
- gonorrhea · score 0.01
- gastric carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCW0-F1 | alphafold | PREDICTED | 76.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCW0.
Amino-acid sequence (462 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KREMEN2?
The strongest Open Targets associations for KREMEN2 are neurodegenerative disease, balding measurement, ependymoma, non-small cell lung carcinoma and calf circumference measurement.
How long is the KREMEN2 protein?
The Homo sapiens KREMEN2 protein (UniProt Q8NCW0) is 462 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCW0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCW0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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