NAD(P)H-hydrate epimerase (NAXE)
Homo sapiens — UniProt Q8NCW5
Data last refreshed: (UniProt release unknown)
Key facts
NAD(P)H-hydrate epimerase (NAXE) is a protein from Homo sapiens identified by UniProt accession Q8NCW5, 288 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q8NCW5; gene symbol NAXE.
- Organism: Homo sapiens.
- Length: 288 amino acids.
- Top disease associations (Open Targets): encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, genetic disorder and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NAD(P)H-hydrate epimerase |
|---|---|
| UniProt accession | Q8NCW5 |
| Gene | NAXE |
| Organism | Homo sapiens |
| Length | 288 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy · score 0.78
- genetic disorder · score 0.18
- blood protein measurement · score 0.13
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.08
- intestinal neoplasm · score 0.04
- atherosclerosis · score 0.04
- aspartate aminotransferase measurement · score 0.03
- glaucoma · score 0.03
- Progressive encephalopathy · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCW5-F1 | alphafold | PREDICTED | 86.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCW5.
Amino-acid sequence (288 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NAXE?
The strongest Open Targets associations for NAXE are encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, genetic disorder, blood protein measurement, neoplasm and hepatocellular carcinoma.
How long is the NAXE protein?
The Homo sapiens NAXE protein (UniProt Q8NCW5) is 288 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCW5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCW5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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