Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11)
Homo sapiens — UniProt Q8NCW6
Data last refreshed: (UniProt release unknown)
Key facts
Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11) is a protein from Homo sapiens identified by UniProt accession Q8NCW6, 608 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q8NCW6; gene symbol GALNT11.
- Organism: Homo sapiens.
- Length: 608 amino acids.
- Top disease associations (Open Targets): Kleefstra syndrome 2, adolescent idiopathic scoliosis and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 11 |
|---|---|
| UniProt accession | Q8NCW6 |
| Gene | GALNT11 |
| Organism | Homo sapiens |
| Length | 608 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- Kleefstra syndrome 2 · score 0.34
- adolescent idiopathic scoliosis · score 0.24
- glioblastoma multiforme · score 0.13
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.06
- nephrotic syndrome · score 0.05
- focal segmental glomerulosclerosis · score 0.05
- congenital nephrotic syndrome, Finnish type · score 0.04
- xanthinuria type II · score 0.04
- pentosuria · score 0.04
- hyperprolinemia type 1 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NCW6-F1 | alphafold | PREDICTED | 85.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NCW6.
Amino-acid sequence (608 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GALNT11?
The strongest Open Targets associations for GALNT11 are Kleefstra syndrome 2, adolescent idiopathic scoliosis, glioblastoma multiforme, familial idiopathic steroid-resistant nephrotic syndrome and nephrotic syndrome.
How long is the GALNT11 protein?
The Homo sapiens GALNT11 protein (UniProt Q8NCW6) is 608 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NCW6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NCW6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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