Uncharacterized protein C3orf20 (C3orf20)

About Uncharacterized protein C3orf20

Uncharacterized protein C3orf20 (C3orf20) is a protein from Homo sapiens identified by UniProt accession Q8ND61, 904 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	Uncharacterized protein C3orf20
UniProt accession	Q8ND61
Gene	C3orf20
Organism	Homo sapiens
Length	904 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.08
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
Female infertility due to fertilization defect · score 0.07
spermatogenic failure 3 · score 0.07
spermatogenic failure 55 · score 0.07
spermatogenic failure 31 · score 0.07
spermatogenic failure 53 · score 0.07
spermatogenic failure 26 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8ND61-F1	alphafold	PREDICTED	58.86	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8ND61.

Amino-acid sequence (904 residues)

MSYIKSNLEL YQQYTAMAPK LLARISKLLM ICQNAGISVP KGIRNIFEFT WEELISDPSV PTPSDILGLE VSFGAPLVVL MEPTFVQVPT LKKPLPPPPP APPRPVLLAT TGAAKRSTLS PTMARQVRTH QETLNRFQQQ SIHLLTELLR LKMKAMVESM SVGANPLDIT RRFVEASQLL HLNAKEMAFN CLISTAGRSG YSSGQLWKES LANMSAIGVN SPYQLIYHSS TACLSFSLSA GKEAKKKIGK SRTTEDVSMP PLHRGVGTPA NSLEFSDPCP EAREKLQELC RHIEAERATW KGRNISYPMI LRNYKAKMPS HLMLARKGDS QTPGLHYPPT AGAQTLSPTS HPSSANHHFS QHCQEGKAPK KAFKFHYTFY DGSSFVYYPS GNVAVCQIPT CCRGRTITCL FNDIPGFSLL ALFNTEGQGC VHYNLKTSCP YVLILDEEGG TTNDQQGYVV HKWSWTSRTE TLLSLEYKVN EEMKLKVLGQ DSITVTFTSL NETVTLTVSA NNCPHGMAYD KRLNRRISNM DDKVYKMSRA LAEIKKRFQK TVTQFINSIL LAAGLFTIEY PTKKEEEEFV RFKMRSRTHP ERLPKLSLYS GESLLRSQSG HLESSIAETL KDEPESAPVS PVRKTTKIHT KAKVTSRGKA REGRSPTRWA ALPSDCPLVL RKLMLKEDTR AGCKCLVKAP LVSDVELERF LLAPRDPSQV LVFGIISSQN YTSTGQLQWL LNTLYNHQQR GRGSPCIQCR YDSYRLLQYD LDSPLQEDPP LMVKKNSVVQ GMILMFAGGK LIFGGRVLNG YGLSKQNLLK QIFRSQQDYK MGYFLPDDYK FSVPNSVLSL EDSESVKKAE SEDIQGSSSS LALEDYVEKE LSLEAEKTRE PEVELHPLSR DSKITSWKKQ ASKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards