ATP-dependent RNA helicase TDRD9 (TDRD9)
Homo sapiens — UniProt Q8NDG6
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent RNA helicase TDRD9 (TDRD9) is a protein from Homo sapiens identified by UniProt accession Q8NDG6, 1382 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.
- UniProt accession: Q8NDG6; gene symbol TDRD9.
- Organism: Homo sapiens.
- Length: 1382 amino acids.
- Top disease associations (Open Targets): azoospermia, male infertility with azoospermia or oligozoospermia due to single gene mutation and male infertility.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent RNA helicase TDRD9 |
|---|---|
| UniProt accession | Q8NDG6 |
| Gene | TDRD9 |
| Organism | Homo sapiens |
| Length | 1382 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (151)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.58
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.38
- male infertility · score 0.35
- unipolar depression · score 0.25
- amino acid measurement · score 0.25
- asparagine measurement · score 0.25
- refractive error · score 0.23
- schizophrenia · score 0.22
- ganglion cell inner plexiform layer thickness measurement · score 0.20
- age at onset · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDG6-F1 | alphafold | PREDICTED | 79.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDG6.
Amino-acid sequence (1382 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TDRD9?
The strongest Open Targets associations for TDRD9 are azoospermia, male infertility with azoospermia or oligozoospermia due to single gene mutation, male infertility, unipolar depression and amino acid measurement.
How long is the TDRD9 protein?
The Homo sapiens TDRD9 protein (UniProt Q8NDG6) is 1382 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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