Islet cell autoantigen 1-like protein (ICA1L)
Homo sapiens — UniProt Q8NDH6
Data last refreshed: (UniProt release unknown)
Key facts
Islet cell autoantigen 1-like protein (ICA1L) is a protein from Homo sapiens identified by UniProt accession Q8NDH6, 482 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.
- UniProt accession: Q8NDH6; gene symbol ICA1L.
- Organism: Homo sapiens.
- Length: 482 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Islet cell autoantigen 1-like protein |
|---|---|
| UniProt accession | Q8NDH6 |
| Gene | ICA1L |
| Organism | Homo sapiens |
| Length | 482 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (148)
Diseases linked to this target (Open Targets).
- platelet count · score 0.43
- mean platelet volume · score 0.39
- urate measurement · score 0.26
- coronary artery disease · score 0.21
- body mass index · score 0.19
- migraine disorder · score 0.19
- white matter microstructure measurement · score 0.18
- urinary albumin to creatinine ratio · score 0.18
- pulse pressure measurement · score 0.18
- white matter hyperintensity measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDH6-F1 | alphafold | PREDICTED | 68.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDH6.
Amino-acid sequence (482 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ICA1L?
The strongest Open Targets associations for ICA1L are platelet count, mean platelet volume, urate measurement, coronary artery disease and body mass index.
How long is the ICA1L protein?
The Homo sapiens ICA1L protein (UniProt Q8NDH6) is 482 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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