Cytosolic carboxypeptidase-like protein 5 (AGBL5)

About Cytosolic carboxypeptidase-like protein 5

Cytosolic carboxypeptidase-like protein 5 (AGBL5) is a protein from Homo sapiens identified by UniProt accession Q8NDL9, 886 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	Cytosolic carboxypeptidase-like protein 5
UniProt accession	Q8NDL9
Gene	AGBL5
Organism	Homo sapiens
Length	886 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.64
Retinal dystrophy · score 0.38
autosomal recessive retinitis pigmentosa · score 0.34
neurodegenerative disease · score 0.30
neutrophil count · score 0.19
genetic disorder · score 0.19
myeloid white cell count · score 0.14
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.08
leukocyte count · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NDL9-F1	alphafold	PREDICTED	69.81	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDL9.

Amino-acid sequence (886 residues)

MELRCGGLLF SSRFDSGNLA HVEKVESLSS DGEGVGGGAS ALTSGIASSP DYEFNVWTRP DCAETEFENG NRSWFYFSVR GGMPGKLIKI NIMNMNKQSK LYSQGMAPFV RTLPTRPRWE RIRDRPTFEM TETQFVLSFV HRFVEGRGAT TFFAFCYPFS YSDCQELLNQ LDQRFPENHP THSSPLDTIY YHRELLCYSL DGLRVDLLTI TSCHGLREDR EPRLEQLFPD TSTPRPFRFA GKRIFFLSSR VHPGETPSSF VFNGFLDFIL RPDDPRAQTL RRLFVFKLIP MLNPDGVVRG HYRTDSRGVN LNRQYLKPDA VLHPAIYGAK AVLLYHHVHS RLNSQSSSEH QPSSCLPPDA PVSDLEKANN LQNEAQCGHS ADRHNAEAWK QTEPAEQKLN SVWIMPQQSA GLEESAPDTI PPKESGVAYY VDLHGHASKR GCFMYGNSFS DESTQVENML YPKLISLNSA HFDFQGCNFS EKNMYARDRR DGQSKEGSGR VAIYKASGII HSYTLECNYN TGRSVNSIPA ACHDNGRASP PPPPAFPSRY TVELFEQVGR AMAIAALDMA ECNPWPRIVL SEHSSLTNLR AWMLKHVRNS RGLSSTLNVG VNKKRGLRTP PKSHNGLPVS CSENTLSRAR SFSTGTSAGG SSSSQQNSPQ MKNSPSFPFH GSRPAGLPGL GSSTQKVTHR VLGPVREPRS QDRRRQQQPL NHRPAGSLAP SPAPTSSGPA SSHKLGSCLL PDSFNIPGSS CSLLSSGDKP EAVMVIGKGL LGTGARMPCI KTRLQARPRL GRGSPPTRRG MKGSSGPTSP TPRTRESSEL ELGSCSATPG LPQARPPRPR SAPAFSPISC SLSDSPSWNC YSRGPLGQPE VCFVPKSPPL TVSPRV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards