Cytosolic carboxypeptidase-like protein 5 (AGBL5)
Homo sapiens — UniProt Q8NDL9
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic carboxypeptidase-like protein 5 (AGBL5) is a protein from Homo sapiens identified by UniProt accession Q8NDL9, 886 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.
- UniProt accession: Q8NDL9; gene symbol AGBL5.
- Organism: Homo sapiens.
- Length: 886 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, Retinal dystrophy and autosomal recessive retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic carboxypeptidase-like protein 5 |
|---|---|
| UniProt accession | Q8NDL9 |
| Gene | AGBL5 |
| Organism | Homo sapiens |
| Length | 886 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (160)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.64
- Retinal dystrophy · score 0.38
- autosomal recessive retinitis pigmentosa · score 0.34
- neurodegenerative disease · score 0.30
- neutrophil count · score 0.19
- genetic disorder · score 0.19
- myeloid white cell count · score 0.14
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- leukocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDL9-F1 | alphafold | PREDICTED | 69.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDL9.
Amino-acid sequence (886 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AGBL5?
The strongest Open Targets associations for AGBL5 are retinitis pigmentosa, Retinal dystrophy, autosomal recessive retinitis pigmentosa, neurodegenerative disease and neutrophil count.
How long is the AGBL5 protein?
The Homo sapiens AGBL5 protein (UniProt Q8NDL9) is 886 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.