Polyhomeotic-like protein 3 (PHC3)
Homo sapiens — UniProt Q8NDX5
Data last refreshed: (UniProt release unknown)
Key facts
Polyhomeotic-like protein 3 (PHC3) is a protein from Homo sapiens identified by UniProt accession Q8NDX5, 983 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q8NDX5; gene symbol PHC3.
- Organism: Homo sapiens.
- Length: 983 amino acids.
- Top disease associations (Open Targets): lean body mass, appendicular lean mass and fat body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Polyhomeotic-like protein 3 |
|---|---|
| UniProt accession | Q8NDX5 |
| Gene | PHC3 |
| Organism | Homo sapiens |
| Length | 983 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.39
- appendicular lean mass · score 0.28
- fat body mass · score 0.28
- systolic blood pressure · score 0.28
- diastolic blood pressure · score 0.28
- body weight · score 0.27
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.26
- glioblastoma multiforme · score 0.26
- body height · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDX5-F1 | alphafold | PREDICTED | 49.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDX5.
Amino-acid sequence (983 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PHC3?
The strongest Open Targets associations for PHC3 are lean body mass, appendicular lean mass, fat body mass, systolic blood pressure and diastolic blood pressure.
How long is the PHC3 protein?
The Homo sapiens PHC3 protein (UniProt Q8NDX5) is 983 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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