Inactive ADP-ribosyltransferase ARH2 (ADPRHL1)
Homo sapiens — UniProt Q8NDY3
Data last refreshed: (UniProt release unknown)
Key facts
Inactive ADP-ribosyltransferase ARH2 (ADPRHL1) is a protein from Homo sapiens identified by UniProt accession Q8NDY3, 354 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q8NDY3; gene symbol ADPRHL1.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): PR interval, hypertrophic cardiomyopathy and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inactive ADP-ribosyltransferase ARH2 |
|---|---|
| UniProt accession | Q8NDY3 |
| Gene | ADPRHL1 |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- PR interval · score 0.32
- hypertrophic cardiomyopathy · score 0.32
- neurodegenerative disease · score 0.27
- intraocular pressure measurement · score 0.12
- IGF-1 measurement · score 0.07
- mean platelet volume · score 0.07
- major depressive disorder · score 0.07
- obsessive-compulsive disorder · score 0.06
- platelet count · score 0.06
- neutrophil percentage of leukocytes · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDY3-F1 | alphafold | PREDICTED | 93.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDY3.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADPRHL1?
The strongest Open Targets associations for ADPRHL1 are PR interval, hypertrophic cardiomyopathy, neurodegenerative disease, intraocular pressure measurement and IGF-1 measurement.
How long is the ADPRHL1 protein?
The Homo sapiens ADPRHL1 protein (UniProt Q8NDY3) is 354 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDY3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDY3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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