Class E basic helix-loop-helix protein 23 (BHLHE23)
Homo sapiens — UniProt Q8NDY6
Data last refreshed: (UniProt release unknown)
Key facts
Class E basic helix-loop-helix protein 23 (BHLHE23) is a protein from Homo sapiens identified by UniProt accession Q8NDY6, 225 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q8NDY6; gene symbol BHLHE23.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): neuroticism measurement, Down syndrome and PR interval.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Class E basic helix-loop-helix protein 23 |
|---|---|
| UniProt accession | Q8NDY6 |
| Gene | BHLHE23 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.13
- Down syndrome · score 0.03
- PR interval · score 0.02
- systolic blood pressure · score 0.02
- breast cancer · score 0.02
- Bartsocas-Papas syndrome 1 · score 0.01
- congenital stationary night blindness · score 0.01
- multiple sclerosis · score 0.01
- obesity · score 0.00
- gastric adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDY6-F1 | alphafold | PREDICTED | 65.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDY6.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BHLHE23?
The strongest Open Targets associations for BHLHE23 are neuroticism measurement, Down syndrome, PR interval, systolic blood pressure and breast cancer.
How long is the BHLHE23 protein?
The Homo sapiens BHLHE23 protein (UniProt Q8NDY6) is 225 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDY6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDY6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.