Transmembrane protein 52 (TMEM52)
Homo sapiens — UniProt Q8NDY8
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 52 (TMEM52) is a protein from Homo sapiens identified by UniProt accession Q8NDY8, 209 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8NDY8; gene symbol TMEM52.
- Organism: Homo sapiens.
- Length: 209 amino acids.
- Top disease associations (Open Targets): body mass index, body weight and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 52 |
|---|---|
| UniProt accession | Q8NDY8 |
| Gene | TMEM52 |
| Organism | Homo sapiens |
| Length | 209 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- body mass index · score 0.33
- body weight · score 0.17
- electrocardiography · score 0.16
- lean body mass · score 0.14
- waist circumference · score 0.14
- lifestyle measurement · score 0.14
- mean corpuscular hemoglobin concentration · score 0.13
- diastolic blood pressure · score 0.12
- blood protein measurement · score 0.12
- systolic blood pressure · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDY8-F1 | alphafold | PREDICTED | 58.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDY8.
Amino-acid sequence (209 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM52?
The strongest Open Targets associations for TMEM52 are body mass index, body weight, electrocardiography, lean body mass and waist circumference.
How long is the TMEM52 protein?
The Homo sapiens TMEM52 protein (UniProt Q8NDY8) is 209 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDY8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDY8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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