BEN domain-containing protein 2 (BEND2)
Homo sapiens — UniProt Q8NDZ0
Data last refreshed: (UniProt release unknown)
Key facts
BEN domain-containing protein 2 (BEND2) is a protein from Homo sapiens identified by UniProt accession Q8NDZ0, 799 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.
- UniProt accession: Q8NDZ0; gene symbol BEND2.
- Organism: Homo sapiens.
- Length: 799 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, azoospermia and partial chromosome Y deletion.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BEN domain-containing protein 2 |
|---|---|
| UniProt accession | Q8NDZ0 |
| Gene | BEND2 |
| Organism | Homo sapiens |
| Length | 799 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (110)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- azoospermia · score 0.10
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failures 50 · score 0.08
- spermatogenic failure 25 · score 0.08
- spermatogenic failure, X-linked, 2 · score 0.08
- spermatogenic failure 63 · score 0.07
- isochromosomy Yp · score 0.07
- spermatogenic failure 61 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDZ0-F1 | alphafold | PREDICTED | 49.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDZ0.
Amino-acid sequence (799 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BEND2?
The strongest Open Targets associations for BEND2 are neurodegenerative disease, azoospermia, partial chromosome Y deletion, male infertility with teratozoospermia due to single gene mutation and spermatogenic failures 50.
How long is the BEND2 protein?
The Homo sapiens BEND2 protein (UniProt Q8NDZ0) is 799 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDZ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDZ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.