Transmembrane protein 161B (TMEM161B)
Homo sapiens — UniProt Q8NDZ6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 161B (TMEM161B) is a protein from Homo sapiens identified by UniProt accession Q8NDZ6, 487 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: Q8NDZ6; gene symbol TMEM161B.
- Organism: Homo sapiens.
- Length: 487 amino acids.
- Top disease associations (Open Targets): body mass index, lean body mass and unipolar depression.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 161B |
|---|---|
| UniProt accession | Q8NDZ6 |
| Gene | TMEM161B |
| Organism | Homo sapiens |
| Length | 487 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- body mass index · score 0.46
- lean body mass · score 0.45
- unipolar depression · score 0.45
- smoking initiation · score 0.43
- systolic blood pressure · score 0.43
- attention deficit hyperactivity disorder · score 0.42
- smoking status measurement · score 0.41
- chronotype measurement · score 0.41
- insomnia measurement · score 0.41
- alcohol consumption measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NDZ6-F1 | alphafold | PREDICTED | 82.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NDZ6.
Amino-acid sequence (487 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM161B?
The strongest Open Targets associations for TMEM161B are body mass index, lean body mass, unipolar depression, smoking initiation and systolic blood pressure.
How long is the TMEM161B protein?
The Homo sapiens TMEM161B protein (UniProt Q8NDZ6) is 487 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NDZ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NDZ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.