Zinc finger protein GLIS3 (GLIS3)
Homo sapiens — UniProt Q8NEA6
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein GLIS3 (GLIS3) is a protein from Homo sapiens identified by UniProt accession Q8NEA6, 775 residues long. MolForge cross-references it against 0 known binders and 261 disease associations.
- UniProt accession: Q8NEA6; gene symbol GLIS3.
- Organism: Homo sapiens.
- Length: 775 amino acids.
- Top disease associations (Open Targets): neonatal diabetes mellitus with congenital hypothyroidism, type 2 diabetes mellitus and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein GLIS3 |
|---|---|
| UniProt accession | Q8NEA6 |
| Gene | GLIS3 |
| Organism | Homo sapiens |
| Length | 775 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (261)
Diseases linked to this target (Open Targets).
- neonatal diabetes mellitus with congenital hypothyroidism · score 0.78
- type 2 diabetes mellitus · score 0.55
- sex hormone-binding globulin measurement · score 0.51
- refractive error measurement · score 0.50
- intraocular pressure measurement · score 0.50
- glucose measurement · score 0.49
- diabetes mellitus · score 0.49
- fasting blood glucose measurement · score 0.49
- type 1 diabetes mellitus · score 0.48
- neuroticism measurement · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NEA6-F1 | alphafold | PREDICTED | 49.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEA6.
Amino-acid sequence (775 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GLIS3?
The strongest Open Targets associations for GLIS3 are neonatal diabetes mellitus with congenital hypothyroidism, type 2 diabetes mellitus, sex hormone-binding globulin measurement, refractive error measurement and intraocular pressure measurement.
How long is the GLIS3 protein?
The Homo sapiens GLIS3 protein (UniProt Q8NEA6) is 775 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NEA6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NEA6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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