Germ cell-less protein-like 2 (GMCL2)
Homo sapiens — UniProt Q8NEA9
Data last refreshed: (UniProt release unknown)
Key facts
Germ cell-less protein-like 2 (GMCL2) is a protein from Homo sapiens identified by UniProt accession Q8NEA9, 526 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.
- UniProt accession: Q8NEA9; gene symbol GMCL2.
- Organism: Homo sapiens.
- Length: 526 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Germ cell-less protein-like 2 |
|---|---|
| UniProt accession | Q8NEA9 |
| Gene | GMCL2 |
| Organism | Homo sapiens |
| Length | 526 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (209)
Diseases linked to this target (Open Targets).
- platelet count · score 0.24
- mean platelet volume · score 0.24
- platelet crit · score 0.23
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 65 · score 0.08
- deafness-infertility syndrome · score 0.08
- spermatogenic failure 56 · score 0.08
- spermatogenic failure 51 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NEA9-F1 | alphafold | PREDICTED | 82.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEA9.
Amino-acid sequence (526 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GMCL2?
The strongest Open Targets associations for GMCL2 are platelet count, mean platelet volume, platelet crit, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the GMCL2 protein?
The Homo sapiens GMCL2 protein (UniProt Q8NEA9) is 526 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NEA9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NEA9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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