Phospholipid phosphatase 5 (PLPP5)

About Phospholipid phosphatase 5

Phospholipid phosphatase 5 (PLPP5) is a protein from Homo sapiens identified by UniProt accession Q8NEB5, 264 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Phospholipid phosphatase 5
UniProt accession	Q8NEB5
Gene	PLPP5
Organism	Homo sapiens
Length	264 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.24
breast adenocarcinoma · score 0.23
Immature Reticulocyte Fraction Measurement · score 0.22
Red cell distribution width · score 0.20
body height · score 0.19
mean platelet volume · score 0.16
total blood protein measurement · score 0.14
urate measurement · score 0.14
schizophrenia · score 0.13
lean body mass · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8NEB5-F1	alphafold	PREDICTED	91.71	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEB5.

Amino-acid sequence (264 residues)

MGKAAAAVAF GAEVGVRLAL FAAFLVTELL PPFQRLIQPE EMWLYRNPYV EAEYFPTKPM FVIAFLSPLS LIFLAKFLKK ADTRDSRQAC LAASLALALN GVFTNTIKLI VGRPRPDFFY RCFPDGLAHS DLMCTGDKDV VNEGRKSFPS GHSSFAFAGL AFASFYLAGK LHCFTPQGRG KSWRFCAFLS PLLFAAVIAL SRTCDYKHHW QDVLVGSMIG MTFAYVCYRQ YYPPLTDAEC HKPFQDKLVL STAQKPGDSY CFDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards