Meiosis-specific nuclear structural protein 1 (MNS1)
Homo sapiens — UniProt Q8NEH6
Data last refreshed: (UniProt release unknown)
Key facts
Meiosis-specific nuclear structural protein 1 (MNS1) is a protein from Homo sapiens identified by UniProt accession Q8NEH6, 495 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: Q8NEH6; gene symbol MNS1.
- Organism: Homo sapiens.
- Length: 495 amino acids.
- Top disease associations (Open Targets): heterotaxy, visceral, 9, autosomal, with male infertility, BMI-adjusted waist-hip ratio and adolescent idiopathic scoliosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Meiosis-specific nuclear structural protein 1 |
|---|---|
| UniProt accession | Q8NEH6 |
| Gene | MNS1 |
| Organism | Homo sapiens |
| Length | 495 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- heterotaxy, visceral, 9, autosomal, with male infertility · score 0.61
- BMI-adjusted waist-hip ratio · score 0.36
- adolescent idiopathic scoliosis · score 0.27
- situs inversus · score 0.27
- Situs inversus totalis · score 0.27
- waist-hip ratio · score 0.25
- mean corpuscular volume · score 0.24
- mean corpuscular hemoglobin · score 0.23
- BMI-adjusted waist circumference · score 0.23
- chronic lymphocytic leukemia · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NEH6-F1 | alphafold | PREDICTED | 81.90 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEH6.
Amino-acid sequence (495 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MNS1?
The strongest Open Targets associations for MNS1 are heterotaxy, visceral, 9, autosomal, with male infertility, BMI-adjusted waist-hip ratio, adolescent idiopathic scoliosis, situs inversus and Situs inversus totalis.
How long is the MNS1 protein?
The Homo sapiens MNS1 protein (UniProt Q8NEH6) is 495 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NEH6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NEH6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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