Phospholipase DDHD1 (DDHD1)
Homo sapiens — UniProt Q8NEL9
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipase DDHD1 (DDHD1) is a protein from Homo sapiens identified by UniProt accession Q8NEL9, 900 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.
- UniProt accession: Q8NEL9; gene symbol DDHD1.
- Organism: Homo sapiens.
- Length: 900 amino acids.
- Top disease associations (Open Targets): Autosomal recessive spastic paraplegia type 28, hereditary spastic paraplegia 28 and hereditary spastic paraplegia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipase DDHD1 |
|---|---|
| UniProt accession | Q8NEL9 |
| Gene | DDHD1 |
| Organism | Homo sapiens |
| Length | 900 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (159)
Diseases linked to this target (Open Targets).
- Autosomal recessive spastic paraplegia type 28 · score 0.75
- hereditary spastic paraplegia 28 · score 0.65
- hereditary spastic paraplegia · score 0.57
- platelet count · score 0.44
- mean platelet volume · score 0.38
- neurodegenerative disease · score 0.37
- platelet component distribution width · score 0.33
- self reported educational attainment · score 0.28
- insomnia · score 0.25
- total blood protein measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8NEL9-F1 | alphafold | PREDICTED | 65.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8NEL9.
Amino-acid sequence (900 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDHD1?
The strongest Open Targets associations for DDHD1 are Autosomal recessive spastic paraplegia type 28, hereditary spastic paraplegia 28, hereditary spastic paraplegia, platelet count and mean platelet volume.
How long is the DDHD1 protein?
The Homo sapiens DDHD1 protein (UniProt Q8NEL9) is 900 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8NEL9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8NEL9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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